Other than the opcache what can require php-fpm to be restarted to see changes?

I have opcache setup as follows:

; When disabled, you must reset the OPcache manually or restart the
; webserver for changes to the filesystem to take effect.
opcache.validate_timestamps=1

; How often (in seconds) to check file timestamps for changes to the shared
; memory storage allocation. ("1" means validate once per second, but only
; once per request. "0" means always validate)
opcache.revalidate_freq=0

When deploying changes, I find that I still need to restart php-fpm to see them.

What other settings should I be investigating?