The service was launched after a gap of 41 years A direct train service linking Wrexham with London via Shropshire is to finish this week, less than three years after it was reinstated.
The service from north Wales to London Marylebone returned in April 2008 after a gap of 41 years.
The Wrexham and Shropshire train company blamed falling customers numbers in the economic downturn.
It said it would help 55 staff find alternative jobs when the service ends on Friday.
They were given the news on Tuesday evening.
The service had run five times a day but then dropped to four and was reduced to three last December.
Those who have used the service have been full of praise, and it scored a remarkable 99% satisfaction rating in an independent survey.
When it launched, the service stopped at 10 stations between Wrexham and London including Shrewsbury, Telford, Wolverhampton and Banbury.
I’m afraid that it was always likely.
Originally this was set up by a rival company to Chiltern, which runs most of the services on that line, and eventually they both became owned by Deutsche Bahn, the German state railway.
So it was no longer really viable for Deutsche Bahn to be running services that were rival to its main franchise services.
They were very nice trains. I did travel on it a couple of times.
It used to be real old-fashioned service, with friendly staff, nice food and a very different atmosphere from the sort of modern glass and aluminium boxes that we’re used to these days.
He was speaking to BBC Radio Wales
The Wrexham, Shropshire and Marylebone Railway Company began as a joint partnership between Renaissance Trains, which runs the Hull to London service, and Laing Rail.
It is now run by Chiltern, an offshoot of DB, the German state railway operator, and has been struggling to gain enough passengers to make it a going concern.
In a letter handed out to passengers at Wrexham General station on Wednesday morning, Wrexham and Shropshire chairman Adrian Shooter said the firm lost £2.8m in 2010.
He said: “We have done everything possible to try to reduce the losses.
“We have reached the conclusion that the business has no prospect of providing a return on investment.”
Mr Shooter said staff were being sought alternative jobs in the railway industry.
He added that Wrexham and Shropshire tickets for after this Friday would be accepted on appropriate Virgin Trains, Arriva Trains Wales, London Midland and Chiltern Railways services to and from London Euston and London Marylebone.
In a statement, the firm said that despite having attempted to increase passenger numbers, it had determined that the business has no prospect of reaching profitability and providing a return on investment.
It said: “Wrexham & Shropshire is not insolvent nor is it being placed in administration and all outstanding financial commitments will be met.
“Alternative employment opportunities within the railway industry are being sought for the 55 employees, and all staff wages and full redundancy entitlements will be paid.”
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