David Cameron will try to move the political debate away from spending cuts to economic growth in his first speech to the CBI as prime minister.
Mr Cameron will tell delegates at the CBI annual conference that he wants to back the big businesses of the future.
The prime minister is also expected to announce a £200m scheme to strengthen ties between universities and industry.
But Labour leader Ed Miliband will claim ministers lack a credible plan for growth when he addresses the forum.
In his first speech to the conference since becoming leader, Mr Miliband will say the government is in danger of repeating the mistakes that led to the recession.
The government has long argued that while 490,000 public sector positions are forecast to close, new jobs will be created by the private sector.
Mr Cameron will tell the CBI conference in London that he knows where economic growth and new jobs will come from.
He will say he wants to help new companies break into existing markets, and will pledge funding for a network of centres to make research more commercial.
Mr Cameron is expected to say: “Over the course of this Parliament – and the next – I believe we can transform our fortunes.
“This is an incredible opportunity for Britain, for new start-ups to flourish, for innovations to drive growth and create jobs.
“To build that new dynamism in our economy, to create the growth, jobs and opportunities Britain needs, we’ve got to back the big businesses of tomorrow, not just the big businesses of today.”
Mr Miliband is expected to tell the CBI that Mr Cameron has failed to learn lessons from the financial crisis and has no plan for growth.
He is set to say to delegates: “As much as I am worried about the job cuts and pace of retrenchment in the government’s deficit reduction plan, I am equally worried about its failure to provide any sort of wider economic policy.
“Without profound change in the way we manage our economy, we are at risk of – at best – sleepwalking back to an economy riddled with the same risks as we saw before the recession hit.”
The CBI itself will argue that levels of taxation and regulation have eroded the UK’s international position.
The political debate at the conference will centre on growth in large part because preliminary GDP figures from the Office for National Statistics for the third quarter of 2010 are due on Tuesday.
Some economists expect them to show slower growth than figures for the previous quarter.
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