Give WordPress Admin interface a complete transformation with Friendly Admin Menu. Use it alone or in addition to the default WordPress Admin Menu.
Easy to use and a more logical menu layout using a tabbed interface with large icons.
Uses built in JQuery library to keep it lightweight and fast loading, does not add any code to your themes.
Respects WordPress capabilities and roles (shows menu items based on user capability.)
Perfect for clients or users that find WordPress Admin Menu confusing.
Includes 4 themes, if you are comfortable with php you can easily make it your own, or include your own theme using JQueryUI Theme Roller and add it to appropriate folder.
Also works with WordPress 3.0 Multisite.