‘More money needed’ for HIV cure

HIV structureHIV finds ways to elude the body’s immune system
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More investment is needed to find a cure for HIV, the new head of the International Aids Society has said.

Bertrand Audoin admits this might take as long as 25 years, but he says a cure is the only way to keep ahead of the HIV epidemic in the long term during tough financial times.

Sunday sees the 30th anniversary of the first medical reports of a new illness.

Some experts have warned that talk of a cure could lead to false hopes, and developing a vaccine would be better.

Mr Audoin said: “It is the right moment – from the scientific and financial point of view – to invest more time and money in researching a cure.

“There is already some basic science in this area. We know that some people who are on HIV treatment can contain the virus in a way which makes them unable to infect other people.

“So we think further work could help us develop a functional cure, which would allow the virus to remain latent in the body, without people feeling sick or needing treatment. That’s the goal.”

Mr Audoin ran a French Aids organisation called Sidaction, before heading the IAS – an organisation of 18,000 health professionals and activists.

“The goal is to allow the virus to remain latent in the body, without people feeling sick or passing on infection.”

Bertrand Audoin International AIDS Society

He said: “At the moment, for every one person beginning treatment in badly affected countries in Africa, two people get infected with HIV in that time.

“So treatment with anti-retroviral drugs isn’t the only solution in the long run.

“It could take 25 years before we find a cure – and the hardest part will be convincing donor governments and other funding organisations to put money into research.

“But if we don’t invest in the science, the epidemic will go faster than our work on it – and the financial situation will make it more difficult to put people on treatment.”

The IAS has convened a working group of international researchers to develop a strategy that might lead to a cure. It is due to deliver a draft report at the end of the year.

The group is co-chaired by Professor Francoise Barre-Sinoussi, who won the Nobel Prize in 2008 for discovering HIV.

A virologist at University College London, Professor Robin Weiss, said: “Much as I would love to see one, the word ‘cure’ can lead to false hopes.

“I don’t believe you can cure HIV infection, but you can keep the amount of virus down.

“I would prefer to see a vaccine so we can stop people being infected in the first place. But we’re still years away from having one for HIV.”

Next week, heads of governments will attend a high-level UN meeting on Aids in New York. Negotiations have already begun to look at the wording of a final declaration.

Mr Audoin said: “Some of us are fighting for very simple words to be put in the declaration – for example, mentioning condoms – but we are not sure if that will happen.

“There is a trend in some governments to think that we’ve done enough on HIV, or that everything has failed. We need to keep developing our programmes.”

This article is from the BBC News website. © British Broadcasting Corporation, The BBC is not responsible for the content of external internet sites.

Acid oceans turn ‘Nemo’ fish deaf

Richard BlackBy Richard Black

ClownfishBaby clownfish face a “wall of mouths” when they first arrive at the reef
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Clownfish, the spectacular tropical species feted in the movie Finding Nemo, appear to lose their hearing in water slightly more acidic than normal.

At levels of acidity that may be common by the end of the century, the fish did not respond to the sounds of predators.

The oceans are becoming more acidic because they absorb much of the CO2 that humanity puts into the atmosphere.

Scientists write in the journal Biology Letters that failing to move away from danger would hurt the fish’s survival.

“Avoiding coral reefs during the day is very typical behaviour of fish in open water,” said research leader Steve Simpson from the School of Biological Sciences at the UK’s Bristol University.

“They do this by monitoring the sounds of animals on the reef, most of which are predators to something just a centimetre in length.

“But sounds are also important for mate detection, pack hunting, foraging – so if any or all of those capacities are gone, you’d have a very lost fish,” he told BBC News.

Previous research has shown that fish also lose their capacity to scent danger in slightly more acidic seawater.

Experimental chamberThe fish were put in a “choice chamber” that allowed them to swim away, or not, on hearing the noise

The team raised baby clownfish in tanks containing water at different levels of acidity.

One resembled the seawater of today, with the atmosphere containing about 390 parts per million (ppm) of carbon dioxide.

Clownfish

The other tanks were set at levels that could be reached later this century – 600, 700 and 900 ppm.

The more CO2 there is in the atmosphere, the more the oceans absorb – and the more they absorb, the more acidic the water becomes.

In this experiment, the fish could decide whether to swim towards or away from an underwater loudspeaker replaying the sounds of predators recorded on a reef, with shrimps and fish that would take a small clownfish.

In water with today’s levels of CO2, the fish spent three-quarters of the time at the opposite end of the tube from the loudspeaker.

But at higher concentrations, they showed no preference. This suggests they could not hear, could not decipher or did not act on the warning signals.

“The reef has been described as ‘a wall of mouths’ waiting to receive the clownfish,” said Dr Simpson.

ACIDIFYING OCEANS

Ocean pH levels (Image: BBC)

The oceans are thought to have absorbed about half of the extra CO2 put into the atmosphere in the industrial ageThis has lowered its pH by 0.1pH is the measure of acidity and alkalinityLiquids lie between pH 0 (very acidic) and pH 14 (very alkaline); 7 is neutralSeawater is mildly alkaline with a “natural” pH of about 8.2The IPCC forecasts that ocean pH will fall by “between 0.14 and 0.35 units over the 21st Century, adding to the present decrease of 0.1 units since pre-industrial times”

“What we have done here is put today’s fish in tomorrow’s environment, and the effects are potentially devastating.”

If it takes several decades for the oceans to reach these more acidic levels, there is a chance, the team says, that fish could adapt.

Whether that can happen is one of the outstanding questions from this research. Another is whether other species are similarly affected.

A third question is why the fish are affected by these slight changes in acidity.

There appears to be no physical damage to their ears; the team suggests there could be some effect on nerves, or maybe they are stressed by the higher acidity and do not behave as they otherwise would.

Further experiments are in train that may answer those questions.

Concern about ocean acidification has arisen considerably more recently than alarm over global warming; but already there is ample evidence that it could bring significant changes to ocean life.

The organisms most directly affected appear to be corals and those that make shells, such as snails.

Just this weekend, another team of researchers published findings from a “natural laboratory” in the seas off Papua New Guinea, where carbon dioxide bubbles into the water from the slopes of a dormant volcano.

This local acidity is too much for most corals; instead, an alternative ecosystem based on seagrasses thrives.

With carbon emissions continuing to rise, researchers predicted most reefs around the world would be in serious trouble before the end of the century.

This article is from the BBC News website. © British Broadcasting Corporation, The BBC is not responsible for the content of external internet sites.

Nato raids ‘killed 700 civilians’

RAF Typhoon aircraft at Gioia del Colle Air Base, ItalyNato says its air raids are to protect Libyan citizens

The Libyan government says Nato air raids have killed more than 700 civilians since bombing began in March.

Spokesman Moussa Ibrahim said more than 4,000 people had been wounded, but gave no evidence to confirm his figures.

Nato has denied killing large numbers of civilians, saying its air strikes are to protect Libyans from Colonel Gaddafi’s forces.

Four powerful explosions were felt in the centre of Tripoli on Tuesday night, Libyan state media reported.

Planes were heard flying over the capital, but it was not possible to determine the targets of the raids.

“If Gaddafi goes, the security valve will disappear – his departure would be the worst case scenario for Libya”

Moussa Ibrahim Libyan government spokesman

Speaking at a news conference in Tripoli, Mr Ibrahim accused Nato of killing and injuring hundreds of Libyan citizens.

“Since March 19, and up to May 26, there have been 718 martyrs among civilians and 4,067 wounded – 433 of them seriously,” Mr Ibrahim said.

He said the figures did not include military casualties.

Foreign reporters in Tripoli have not been shown evidence of mass civilian casualties.

Asked why not, Mr Ibrahim said casualties had not been concentrated near the capital but scattered across the country.

He also denied that South African President Jacob Zuma, who met Col Gaddafi in Tripoli on Monday, had discussed an “exit strategy” with the Libyan leader.

“If Gaddafi goes, the security valve will disappear. His departure would be the worst case scenario for Libya,” he told reporters.

Moussa IbrahimMoussa Ibrahim denied that Col Gaddafi had discussed a strategy for his departure

A statement released by Mr Zuma’s office after he returned to Pretoria said Mr Gaddafi would not leave Libya, despite growing international pressure.

“Col Gaddafi called for an end to the bombings to enable a Libyan dialogue,” the statement read.

“He emphasised that he was not prepared to leave his country, despite the difficulties.”

After initially backing Nato’s involvement, Mr Zuma and the African Union have called for a halt to air strikes, arguing that Nato has overstepped its UN mandate to protect civilians.

Both Libyan rebels and Nato have refused to accept a ceasefire until Col Gaddafi agrees to step down.

On Tuesday, Italy’s Foreign Minister Franco Frattini said that Gaddafi’s regime was “finished”, during a visit to the rebel capital Benghazi, in eastern Libya.

“He [Gaddafi] must leave office, he must leave the country,” Mr Frattini told a joint news conference with Ali al-Essawi, the rebels’ foreign affairs chief.

“His aides have left, he has no international support, the G8 leaders reject him, he must go.”

This article is from the BBC News website. © British Broadcasting Corporation, The BBC is not responsible for the content of external internet sites.

Beer market

Man drinking beerDuring the past decade, beer sales in Russia have risen by more than 40%

In a bar in the heart of St Petersburg, widescreen TVs show a match between local football team Zenit and Bayern Munich, two giants of European football – but this is not the only thing these two cities have in common.

While Munich is Europe’s beer capital, St Petersburg is the beer capital of Russia.

It may seem like sacrilege in a country famed for its vodka, but this bar is devoted to the amber nectar – the ideal place to find out why a growing number of young Russians are swapping vodka for beer.

“Vodka is a heavy drink that not everyone likes and the quality of vodka has got worse,” a young Russian women tells me over her pint.

“And it is easier for young people to buy beer, they don’t sell vodka to under-18s in shops,” her friend says.

Another punter tells me more bluntly: “Vodka turns people into animals and beer doesn’t.”

During the past decade, beer sales in Russia have risen by more than 40%, while vodka sales have fallen by nearly 30%.

It is now the fourth largest beer market in the world, after China, the US and Brazil.

Beer is marketed and consumed as a healthier alternative to vodka. It is common to see people swigging from cans in the street and in parks, as if they are drinking Coca-Cola.

And incredibly beer is not even classified as an alcoholic drink in Russia.

But this popularity is causing concern, particularly for the government.

Baltika's flagship brewery in St PetersburgBaltika has about 40% of the Russian beer market

Russians’ alcohol consumption is already twice the critical norm set by the World Health Organisation, and male life expectancy is falling.

“Alcohol consumption has been growing really fast,” Viktor Zvagelsky, State Duma Deputy tells the BBC’s Russia Business Report.

He says the main problem is there are no proper laws to deal with it or programmes to promote healthy living.

“This is one of the main tasks for the government and it has been highlighted by both the president and prime minister,” says Mr Zvagelsky.

So after years of bumper profits, the Russian beer industry has been hit where it hurts, with higher taxes.

In 2010 the tax on beer went up by a staggering 200%.

Zvagelsky believes the tax hike is long overdue.

“Beer has been taxed differently in the past which helped beer companies sell huge volumes and spend a lot of money on advertising and promotion, without having to worry about anything else,” he says.

But, Mr Zvagelsky says, beer should be subject to the same restrictions as other alcohol.

“Even now beer is cheap, 200% tax is not enough. We have more plans to increase the tax on vodka by 120% and beer by 80%,” he says.

Teenager drinking beerRussian’s alcohol consumption is twice the critical norm set by the World Health Organisation

All this is bad news for the world’s biggest brewers. More than 80% of the Russian beer market is controlled by just five players: Baltika Breweries, SUN InBev, Heineken, Efes and SABMiller Rus.

With sales in mature markets such as Western Europe flat, they have invested billions of dollars in Russia.

As Carlsberg might say, it is probably the best market in the world. The Danish brewing giant owns Russia’s biggest beer company Baltika, which has about 40% of the market.

Eastern Europe, which includes Russia, accounts for about a third of Carlsberg’s revenue but almost half its profits.

International brewers have helped develop the market both in terms of investment in production, and also promotion and marketing.

One of the best examples of this is Baltika’s flagship brewery in St Petersburg, now the biggest brewery in Europe.

As well as producing beer for Russia, it exports the famous Japanese beer Asahi all over Europe.

The air here is thick with the smell of fermenting malt and hops.

We walk through a narrow corridor lined with hundreds of vats, and into the brewhouse. Open a vat and you will see a huge, swirling head of beer about 3m (10ft) wide.

You would not want to get lost here. The building is huge.

We walk down endless corridors and across numerous bridges.

When we finally reach the warehouse, it is the size of three football pitches.

We met Baltika’s head of corporate affairs Alexey Kedrin in the microbrewery, where they experiment with new flavours.

A pint of beerBeer sales fell by 15% in Russia during the past two years

After tasting the latest brew, a one-day-old Imperial Stout, he tells me how the government tax hike is hitting business.

“We had to cut down on all our extra expenses, stop some programmes, like administration and the amount of water we use in production,” says Mr Kedrin.

Also, he says, they could not avoid raising the price of their products by an average of 25% in 2010.

He says he does not know why the tax on beer was raised so much, but suggests that “it may be that the influence of the spirits and vodka lobby on the government and state Duma turned out to be significant”.

This is contested by the spirits industry.

“The criticism from beer companies is emotional”, Maxim Chernigovsky, from the Alcohol Market Professionals Club, which represents spirit makers around Russia, told the BBC.

He says beer companies are lobbying to defend their own interests, adding they enjoy more preferences than the producers of strong alcohol drinks.

“The excise tax on vodka is 10 times higher than beer, so the difference is obvious,” says Mr Chernigovsky.

There is definitely a tension between the two titans of Russia’s drinks industry.

The beer industry may be backed by billions of dollars of foreign funds, but they feel powerless against Russia’s vodka lobby, which they say has more political influence.

Russian politicians have been reluctant to take on the vodka industry in the past.

Soviet leader Mikhail Gorbachev was the last leader to seriously clamp down on vodka and once he did so, government revenues and his popularity both plummeted.

But with the government set to significantly raise taxes on both beer and vodka, it looks as though both sides could lose.

This will be bad news for brewers such as Baltika, which are still recovering from last year’s tax hike.

That, coupled with the economic crisis, has seen beer sales fall by 15% during the past two years.

But the brewers point out there is room for more growth in this market, as Russians still drink less beer per person than in Western Europe.

Also, beer sales have started to level out – but it is too early for Russia’s brewers to toast a recovery.

This article is from the BBC News website. © British Broadcasting Corporation, The BBC is not responsible for the content of external internet sites.

Decision due on unsolicited loan offers

Mobile phone in handsRogue traders contact people initially through a text message

A decision over whether action should be taken against firms making unsolicited loan offers is due from the fair trading regulator later.

The Office of Fair Trading (OFT) must decide whether to intervene following a super-complaint from Citizens Advice.

The group said that unscrupulous firms were charging hefty up-front fees after offering to find loans for people who were desperate for cash.

Some loans failed to materialise and calls to the firms were expensive.

Citizens Advice said that the current economic conditions were providing “fertile ground” for rogue credit businesses, with many households facing financial difficulties.

The charity said it had spoken to people in England, Wales and Scotland who had suffered at the hands of unscrupulous credit firms.

In these cases, people had received a text message or telephone call from a firm offering to find them an unsecured loan.

Those who accepted were then charged large up-front fees for little or no service in return.

What is a super-complaint?A designated consumer group can make a super-complaint to the Office of Fair Trading (OFT) if an issue is “significantly harming the interests of consumers”The OFT has 90 days to respond by stating what action, if any, it plans to take on the issue and the reasons behind its decision

Other victims were persuaded to hand over their bank details and later found that money had been taken from their account without their permission.

Victims struggled to get somebody to deal with the issue, and were charged a premium rate when calling to complain.

They also found that, instead, they were being inundated by calls and text messages offering loans or debt management services from other firms.

The OFT must respond to this super-complaint from Citizens Advice within 90 days of it being made. The deadline for that response is on Wednesday.

The Association of Business Recovery Professionals, which represents legitimate debt management companies, has also called for the OFT to step up regulation of the industry.

This article is from the BBC News website. © British Broadcasting Corporation, The BBC is not responsible for the content of external internet sites.

Sprint moves to block mobile deal

AT&T and T-Mobile logosThe combined mobile phone company would have about 43% of the US market
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US mobile network provider Sprint Nextel has asked US regulators to block AT&T’s takeover of T-Mobile USA, saying the deal would harm competition.

Sprint has been the most vocal opponent of the $39bn (£24bn) deal that would create the largest US wireless network.

It argued the deal had “no public interest benefit”, in a filing at the Federal Communications Commission.

Forcing AT&T to divest assets would not be enough to prevent “serious anti-competitive harms”, it added.

“This proposed takeover puts our mobile broadband future at a crossroads,” said Sprint’s Vonya McCann in a statement.

“We can choose the open, competitive road best travelled, and protect American consumers, innovation and our economy, or we can choose the dead end that merely protects only AT&T and leads the rest of us back down the dirt road to Ma Bell.”

Sprint, the third biggest mobile operator in the US, also said the deal would lead to higher prices for consumers.

AT&T agreed to buy T-Mobile from Deutsche Telekom in March, but the deal still needs approval from regulators.

If approved, it would give AT&T about 43% of the US mobile market, taking it ahead of industry leader Verizon Wireless.

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AUDIO: Consternation as Radio 4’s pips go missing

Radio 4’s pips die at the start of the flagship news programme PM with Eddie Mair

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VIDEO: Mladic extradited to The Hague

The former Bosnian Serb General, Ratko Mladic, is in UN custody at a detention centre in the Netherlands where he will await trial on charges of war crimes and genocide.

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Syria declares ‘general amnesty’

Police man towards a man in Baniyas, Syria, 27 May 2011The announcement comes amid ongoing protests and clashes

Syrian President Bashar al-Assad has issued a decree granting a general amnesty, state media say.

The amnesty would cover political opposition movements, including the outlawed Muslim Brotherhood, the reports said.

President Assad has faced months of protests against his rule.

Authorities have cracked down on demonstrators, killing more than 1,000 people and arresting at least 10,000 more, according to human rights groups.

The government has also offered some political concessions, but protesters have dismissed these as largely cosmetic.

Late on Tuesday, state TV repeatedly flashed an “urgent” caption announcing the amnesty.

“President Assad grants a general pardon for the crimes committed before 31 May,” it said.

“The pardon includes all those who belong to political movements, including the Muslim Brotherhood.”

The announcement came as army forces using tanks were reported to be attacking two towns in central Syria, Talbisa and Rastan, where protests have continued.

Foreign journalists have been prevented from entering Syria, and reports of violence are hard to verify.

The BBC’s Jim Muir reports from neighbouring Lebanon that the amnesty had been anticipated.

He says it is also expected that Syrian authorities will launch an attempt at national dialogue in the next few days, though it is not clear who they intend to talk to.

The success of any dialogue in defusing the crisis will depend on how credible the amnesty turns out to be, and is unlikely to get far if heavy-handed repression continues on the ground, our correspondent adds.

In an initial reaction, Syrian activists in Turkey described the amnesty as “too little too late”.

“This measure is insufficient,” Abdel Razak Eid, an activist from the “Damascus Declaration” movement told AFP news agency.

“We are united under the slogan: the people want the fall of the regime and all those who have committed crimes brought to account.”

The Muslim Brotherhood has supported but not initiated the current uprising.

The banned political movement was behind a 1982 uprising in the city of Hama that was ruthlessly repressed, with at least 10,000 killed.

Membership of the group is punishable by death, though this has not been enforced.

In March this year, shortly before protests escalated, President Assad issued an amnesty for those convicted of minor crimes and prisoners over the age of 70.

In April, the president lifted decades-old emergency laws, but violence by the security forces was widely seen to have got worse following the announcement.

The government has blamed the unrest on armed groups, Islamists and foreign agitators.

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Trott named cricketer of the year

Batsman Jonathan Trott is named as the England and Wales Cricket Board Men’s cricketer of the year, as chosen by the British media.

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Mancienne makes move to Hamburg

Chelsea defender Michael Mancienne signs for German side Hamburg after passing a medical.

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NHS ‘listening exercise’ to close

Health officials say they have received around 15,000 website responses and 720 letters during their “listening exercise” on the NHS in England.

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Care home firm agrees rent deal

Troubled care home operator Southern Cross agrees a deal with its landlords to defer 30% of its rent for four months.

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Pakistani journalist found dead

A Pakistani journalist who was feared abducted after he went missing on Sunday has been found dead, his family confirms.

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Judge criticises two rugby stars

A judge criticises two Wales rugby stars after they fail to turn up at court to give evidence against a man accused of assaulting them.

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