How to access Ms Access database from browser in this day and age?

I have an Excel workbook full of macros and Ms Access database to store data. The idea is to have a portable software with minimum dependency of host computer. Developing that is major pain in 2022 AD.

I was planning on rewriting it for web UI to drop one dependency, but it would still need to use Ms Access (security and backwards compatibility).

Is there anyway to access the Access with javascript? I find references to now-buried ActiveX components and ODBC settings on Windows, but is that all there is? No workarounds that would enable modern UI for Access on a local computer?

What alternatives do I have should I consider different database engine? The requirements are simple: it needs to run when opening “mysheets.html” from local hard drive to a browser, have no dependencies to configuration of host computer, needs to be able to travel on usb-stick and have password protection for data (any is better than none). It’s acceptable to make it interop with local exe-files (that can travel with), if possbile.

I would rather not use Node for this, but looks like it’s one option (trading a dependency to another). Nothing that needs to be built and does not make source code “available” in the application does not work, the source code cannot be lost under any circumstances (high mobility).