The M8 has been closed westbound in North Lanarkshire due to black ice, causing major rush hour traffic delays.
The main route from Edinburgh to Glasgow was shut at about 0700 GMT as gritters tried to clear the motorway.
Police said the road, which was closed for two days last month due to snow and ice, was “undriveable”.
Officers are directing traffic off the M8 at Junction 5 Shotts and traffic is rejoining at junction 6 Newhouse. There are also delays eastbound.
As many people headed back to work after the festive holidays, the Met Office issued severe weather warnings for icy roads throughout Scotland.
There were also warnings for heavy snow in the Highlands and parts of Strathclyde.
The M9 northbound was also closed after a four-vehicle collision near junction eight.
Police said the carriageway was blocked and fire and ambulance services were also attending.
Traffic was diverted along the M876, and motorists were advised to avoid the area.
There were several collisions on the M876, but no one was injured.
A lorry jackknifed on the A701, blocking the road in both directions at 0530 GMT, north of Moffat.
The A9 was closed in both directions near Auchterarder in Perthshire after a teenage girl was struck by a car on Tuesday night.
Tayside Police said there had also been a spate of “bumps and scrapes” throughout the force area as temperatures fell.
Northern Constabulary said snow was affecting driving condtions on the A82 at Glencoe.
A Met Office spokesman said: “Following Tuesday’s rain, icy stretches will continue to affect untreated roads and pavements during the morning, especially across northern England, Northern Ireland and southern Scotland.
“Another band of rain, sleet and snow will spread from the west, giving accumulations of 5cm to 10cm of snow over Scotland on ground above around 100 metres, particularly away from low lying areas.”
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